Ankylosing spondylitis (AS; also known as Bechterew’s disease; Bechterew syndrome; Marie Strümpell disease / Marie Struempell disease / Spondyloarthritis) is a chronic, painful, degenerative inflammatory arthritis primarily affecting spine and sacroiliac joints, causing eventual fusion of the spine; it is a member of the group of the autoimmune spondyloarthropathies with a probable genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine.^[1]

Signs and symptoms of Ankylosing spondylitis

The typical patient is young, of 15 to 30 years of age, with chronic pain and stiffness in the lower part of the spine. Men are affected more than women by a ratio in excess of 2:1.^[2] In 40% of cases, ankylosing spondylitis is associated with iridocyclitis causing eye pain and photophobia (increased sensitivity to light). Other common symptoms are recurring mouth ulcers (aphthae) and fatigue. Pain can fluctuate from one side to the other.

Typical prodromes (early symptoms) may occur at a very young age (e.g., 3 years old), when the patient may experience recurring painful joints (e.g. knees, elbows) commonly misinterpreted as simple rheumatism.

AS is also associated with ulcerative colitis, Crohn’s disease, psoriasis, and Reiter’s disease.

Diagnosis for Ankylosing spondylitis

There is no direct test to diagnose AS. A clinical examination and X-ray studies of the spine, which show characteristic spinal changes and sacroiliitis, are the major diagnostic tools. A drawback of X-ray diagnosis is that signs and symptoms of AS have usually been established as long as 8-10 years prior to X-ray-evident changes occurring on a plain film X-ray, which means a delay of as long as 10 years before adequate therapies can be introduced. Options for more accurate (and much earlier) diagnosis are tomography and magnetic resonance imaging of the sacroiliac joints. The Schober’s test is a useful clinical measure of flexion of the lumbar spine performed during examination.^[3]

During acute inflammatory periods, AS patients will usually show an increase in the blood concentration of C-reactive protein (CRP) and an increase in the erythrocyte sedimentation rate (ESR).

Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the HLA-B27 variant are at a higher risk than the general population of developing the disorder. HLA-B27, demonstrated in a blood test, is occasionally used as a diagnostic but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people that have been diagnosed with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries).

In 2007, a collaborative effort by an international team of researchers in the U.K., Australia and the United States led to the discovery of two genes, ARTS1 and IL23R, that also cause AS. The findings were published in the November 2007 edition of Nature Genetics, a journal that emphasizes research on the genetic basis for common and complex diseases.^[4] Together with HLA-B27, these two genes account for roughly 70 percent of the overall incidence of the disease.

The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), developed in Bath (UK), is an index designed to detect the inflammatory burden of active disease. The BASDA can help to establish a diagnosis of AS in the presence of other factors such as HLA-B27 positivity, persistent buttock pain which resolves with exercise, and X-ray or MRI evident involvement of the sacroiliac joints. (See: “Diagnostic Tools”, below)^[5] It can be easily calculated and accurately assesses a patient’s need for additional therapy; a patient with a score of 4 out of a possible 10 points while on adequate NSAID therapy is usually considered a good candidate for biologic therapy.

The Bath Ankylosing Spondylitis Functional Index (BASFI) is a functional index which can accurately assess a patient’s functional impairment due to the disease as well as improvements following therapy. (See: “Diagnostic Tools”, below)^[6] The BASFI is not usually used as a diagnostic tool but rather as a tool to establish a patient’s current baseline and subsequent response to therapy.

Pathophysiology

AS is a systemic rheumatic disease and is one of the seronegative spondyloarthropathies. About 90% of the patients express the HLA-B27 genotype. Tumor necrosis factor-alpha (TNF ?) and IL-1 are also implicated in ankylosing spondylitis. Although specific autoantibodies cannot be detected, its response to immunosuppresive medication has prompted its classification as an autoimmune disease.

Hypotheses on its pathogenesis include a cross-reaction with antigens of the Klebsiella bacterial strain (Tiwana et al. 2001).^[7] Particular authorities argue that elimination of the prime nutrients of Klebsiella (starches) would decrease antigenemia and improve the musculoskeletal symptoms. On the other hand, Khan (2002) argues that the evidence for a correlation between Klebsiella and AS is circumstantial so far, and that the efficacy of low-starch diets has not yet been scientifically evaluated.^[8] Similarly, Toivanen (1999) found no support for the role of klebsiella in the etiology of primary AS.^[9]

Epidemiology

The sex ratio is 3:1 for men:women. In the USA, the prevalence is 0.25%, but as it is a chronic condition the incidence (number of new cases) is fairly low. Many rheumatologists believe the number of women with AS is underdiagnosed, as women tend to manifest symptoms in their lower spinal area (lumbar, sacrum, hips, pelvis) instead of their shoulders/upper chest/neck (where the first symptoms appear in male patients)^[10].

History

It has been suggest that AS was first recognized as a disease which was different from rheumatoid arthritis by Galen as early as the second century A.D.^[11]; however, skeletal evidence of the disease (ossification of joints and entheses primarily of the axial skeleton, known as “bamboo spine”) was first discovered in an archaeological dig that unearthed the skeletal remains of a 5000-year–old Egyptian mummy with evidence of “bamboo spine”.^[12]

The anatomist and surgeon Realdo Colombo described what could have been the disease in 1559,^[13] and the first account of pathologic changes to the skeleton possibly associated with AS was published in 1691 by Bernard Connor.^[14] In 1818, Benjamin Brodie became the first physician to document that a patient believed to have active AS had accompanying iritis.^[15] In 1858, David Tucker published a small booklet which clearly described a patient by the name of Leonard Trask who suffered from severe spinal deformity subsequent to AS.^[16][17] In 1833 Trask fell from a horse, exacerbating the condition and resulting in severe deformity. Tucker reported:

This account became the first documented case of AS in the United States, since its indisputable description of inflammatory disease characteristics of AS, and the hallmark of deforming injury in AS.

It was not until the late nineteenth century (1893-1898), however, when the neurophysiologist Vladimir Bekhterev of Russia in 1893,^[18] Adolph Strümpell of Germany in 1897,^[19] and Pierre Marie of France in 1898,^[20] were the first to give adequate descriptions which permitted an accurate diagnosis of AS prior to severe spinal deformity. For this reason, AS is also known as Bechterew Disease or Marie–Strümpel Disease.

Prognosis of Ankylosing spondylitis

AS can range from mild to progressively debilitating and from medically controlled to refractive.

Unattended cases of AS normally lead to knee pain and may be accompanied by dactylitis or enthesitis, which may result in a misdiagnosis of normal rheumatism. In a long-term undiagnosed period, osteopenia or osteoporosis of the AP spine may occur, causing eventual compression fractures and a back “hump” if untreated. Typical signs of progressed AS are the visible formation of syndesmophytes on X-rays and abnormal bone outgrowths similar to osteophytes affecting the spine. The fusion of the vertebrae paresthesia is a complication due to the inflammation of the tissue surrounding nerves.

Organs commonly affected by AS, other than the axial spine and other joints, are the heart, lungs, colon, and kidney. Other complications are aortic regurgitation, Achilles tendinitis, AV node block and amyloidosis.^[21] Owing to lung fibrosis, chest X-rays may show apical fibrosis while pulmonary function testing may reveal a restrictive lung defect. Very rare complications involve neurologic conditions such as the cauda equina syndrome.^[22][21]

Therapy

No cure is known for AS, although treatments and medications are available to reduce symptoms and pain.

Physical therapy and exercise, along with medication, are at the heart of therapy for ankylosing spondylitis. Physiotherapy and physical exercises are clearly to be preceded by medical treatment in order to reduce the inflammation and pain and are commonly followed by a physician. This way the movements will help in diminishing pain and stiffness, while exercise in an active inflammatory state will just make the pain worse.

Medical professionals and experts in AS have widely speculated that maintaining good posture can reduce the likelihood of a fused or curved spine which occurs in a significant percentage of diagnosed persons. ^[23][24]

Medication

There are three major types of medications used to treat ankylosing spondylitis.

• Anti-inflammatory drugs, which include NSAIDs such as aspirin, ibuprofen, indometacin, naproxen and COX-2 inhibitors, which reduce inflammation, and consequently pain. These drugs tend to have a personal response to the pain and inflammation, although commonly used anti-inflammatory drugs like nimesulide are less effective than others. Opioid analgesics have also been proven by clinical evidence to be very effective in alleviating the type of chronic pain commonly experienced by those suffering from AS, especially in low dose time-release formulations. While NSAIDs should generally be tried first, the use of opioid analgesics either apart from or in concert with NSAIDs should not be summarily dismissed for fear of addiction, as studies have shown that patients who properly take opioid analgesics for pain rarely suffer from addiction as a result of using such opioid therapy for pain relief purposes.
• DMARDs such as cyclosporin, methotrexate, sulfasalazine, and corticosteroids, used to reduce the immune system response through immunosuppression;
• TNF? blockers (antagonists) such as etanercept, infliximab and adalimumab (also known as biologics), are indicated for the treatment of and are effective immunosuppressants in AS as in other autoimmune diseases;

TNF? blockers have been shown to be the most promising treatment, slowing the progress of AS in the majority of clinical cases. They have also been shown to be highly effective in treating not only the arthritis of the joints but also the spinal arthritis associated with AS. A drawback is the fact that these drugs increase the risk of infections. For this reason, the protocol for any of the TNF-? blockers include a test for tuberculosis (like Mantoux or Heaf) before starting treatment. In case of recurrent infections, even recurrent sore throats, the therapy may be suspended because of the involved immunosuppression.

Surgery

In severe cases of AS, surgery can be an option in the form of joint replacements, particularly in the knees and hips. Surgical correction is also possible for those with severe flexion deformities (severe downward curvature) of the spine, particularly in the neck, although this procedure is considered risky.

In addition, AS can have some manifestations which make anaesthesia more complex.

Changes in the upper airway can lead to difficulties in intubating the airway, spinal and epidural anaesthesia may be difficult owing to calicification of ligaments, and a small number have aortic regurgitation. The stiffness of the thoracic ribs results in ventilation being mainly diaphragm-driven, so there may be a decrease in pulmonary function.

Physical therapy

All physical therapies must be approved in advance by a rheumatologist, since movements that normally have great benefits to one’s health may harm a patient with AS; massages and physical manipulations should be practiced by therapists familiar with this disease. Some of the therapies that have been shown to benefit AS patients include:

• Physical therapy/Physiotherapy, shown to be of great benefit to AS patients;
• Swimming, one of the preferred exercises since it involves all muscles and joints in a low gravity environment;
• Slow movement muscle extending exercises like stretching, yoga, tai chi, Pilates method, etc.

Moderate-to-high impact exercises like jogging are generally not recommended or recommended with restrictions due to the jarring of affected vertabrae that can worsen pain and stiffness in some patients.

Alternative medicine

Although the effectiveness of alternative medicines has not been proved by any clinical trial, some patients find some relief in adding these alternative treatments to the medicaments and physical exercises, such as a starch-free diet^[25] (also known as the No Starch Diet or NSD).^[26][27][28] Some patients may find relief from acupuncture treatments. This is administered at various points directly on the spine where the pain is located, although efficacy is uncertain. Herbal medicine may also relieve pain.^[29]

Famous persons afflicted with AS

Well known sufferers of AS include:

• Taiwanese musician Jay Chou^[30][31]
• Mötley Crüe’s guitarist Mick Mars
• Former England cricket captain Mike Atherton
• Former Australian cricketer Michael Slater
• British comedian Lee Hurst
• Canadian radio personality Mike Stafford
• Former Canadian radio personality Dave MacDonald
• Norwegian Prime Minister Jens Stoltenberg
• Norwegian actor Ole-Jørgen Nilsen
• World Chess Champion Vladimir Kramnik^[32]
• Former author and Saturday Review editor Norman Cousins;^[33]
• Scottish former snooker player Chris Small;
• Former US Major League baseball player Rico Brogna;
• Ed Sullivan, the Ed Sullivan Show, US
• Czech writer Karel ?apek^[34];
• British golfer Ian Woosnam;
• Hong Kong Actress Ada Choi.

Additional images

Morbus Bechterew

MRI of SI joints

Homeopathy Treatment for Ankylosing spondylitis

Keywords: homeopathy, homeopathic, treatment, cure, remedy, remedies, medicine

Homeopathy treats the person as a whole. It means that homeopathic treatment focuses on the patient as a person, as well as his pathological condition. The homeopathic medicines are selected after a full individualizing examination and case-analysis, which includes the medical history of the patient, physical and mental constitution, family history, presenting symptoms, underlying pathology, possible causative factors etc. A miasmatic tendency (predisposition/susceptibility) is also often taken into account for the treatment of chronic conditions. A homeopathy doctor tries to treat more than just the presenting symptoms. The focus is usually on what caused the disease condition? Why ‘this patient’ is sick ‘this way’. The disease diagnosis is important but in homeopathy, the cause of disease is not just probed to the level of bacteria and viruses. Other factors like mental, emotional and physical stress that could predispose a person to illness are also looked for. No a days, even modern medicine also considers a large number of diseases as psychosomatic. The correct homeopathy remedy tries to correct this disease predisposition. The focus is not on curing the disease but to cure the person who is sick, to restore the health. If a disease pathology is not very advanced, homeopathy remedies do give a hope for cure but even in incurable cases, the quality of life can be greatly improved with homeopathic medicines.

The homeopathic remedies (medicines) given below indicate the therapeutic affinity but this is not a complete and definite guide to the homeopathy treatment of this condition. The symptoms listed against each homeopathic remedy may not be directly related to this disease because in homeopathy general symptoms and constitutional indications are also taken into account for selecting a remedy. To study any of the following remedies in more detail, please visit the Materia Medica section at Hpathy.

None of these medicines should be taken without professional advice and guidance.

Homeopathy Remedies for Ankylosing spondylitis :

Aesc., agar., arg-m., caust., cimic., con., kali-c., kalm., nat-m., rhus-t.

References