Bronchiectasis is a disease that causes localized, irreversible dilatation of part of the bronchial tree. Involved bronchi are dilated, inflamed, and easily collapsible, resulting in airflow obstruction and impaired clearance of secretions. Bronchiectasis is associated with a wide range of disorders, but it usually results from necrotizing bacterial infections, such as infections caused by the Staphylococcus or Klebsiella species or Bordetella pertussis.
Rene Theophile Hyacinthe Laënnec, the man who invented the stethoscope, used his creation to first discover bronchiectasis in 1819.. The disease was researched in greater detail by Sir William Osler in the late 1800s; in fact, it is suspected that Osler actually died of complications from undiagnosed bronchiectasis.
Dilation of the bronchial walls results in airflow obstruction and impaired clearance of secretions because the dilated areas disrupt normal air pressure in the bronchial tubes, causing sputum to pool inside the dilated areas instead of being pushed upward. The pooled sputum provides an environment conducive to the growth of infectious pathogens, and these areas of the lungs are thus very vulnerable to infection. The more infections that the lungs experience, the more damaged the lung tissue and alveoli become. When this happens, the bronchial tubes become more inelastic and dilated, creating a self-perpetuating cycle of further damage to the lungs.
There are three types of brochiectasis, varying by level of severity. Fusiform (cylindrical) bronchiectasis (the most common type) refers to mildly inflamed bronchi that fail to taper distally. In varicose bronchiectasis, the bronchial walls appear beaded, because areas of dilation are mixed with areas of constriction. Saccular (cystic) bronchiectasis is characterized by severe and irreversible ballooning of the bronchi peripherally, with or without air-fluid levels. Chronic productive cough is prominent, occurring in up to 90% of patients with bronchiectasis. Sputum is produced on a daily basis in 76% of patients.
Generally, persons suffering from bronchiectasis tend to be infected by Haemophilus influenzae early on in the disease course. Secondary infection is usually due to Staphylococcus aureus; followed by Moraxella catarrhalis and finally Pseudomonas aeruginosa.
Causes of Bronchiectasis
There are both congenital and acquired causes of bronchiectasis. Kartagener syndrome, which affects the mobility of cilia in the lungs, aids in the development of the disease. Another common genetic cause is cystic fibrosis, in which a small number of patients develop severe localized bronchiectasis. Young’s syndrome, which is clinically similar to cystic fibrosis, is thought to significantly contribute to the development of bronchiectasis. This is due to the occurrence of chronic, sinopulmonary infections. Patients with alpha 1-antitrypsin deficiency have been found to be particularly susceptible to bronchiectasis, for unknown reasons.  Other less-common congenital causes include primary immunodeficiencies, due to the weakened or nonexistent immune system response to severe, recurrent infections that commonly affect the lung.
Acquired bronchiectasis occurs more frequently, with one of the biggest causes being tuberculosis. Endobronchial tuberculosis commonly leads to bronchiectasis, either from bronchial stenosis or secondary traction from fibrosis. An especially common cause of the disease in children is acquired immune deficiency syndrome, stemming from the human immunodeficiency virus. This disease predisposes patients to a variety of pulmonary ailments, such as pneumonia and other opportunistic infection.. Bronchiectasis can sometimes be an unusual complication of inflammatory bowel disease, especially ulcerative colitis. It can occur in Crohn’s disease as well, but does so less frequently. Bronchiectasis in this situation usually stems from various allergic responses to inhaled fungus spores. Recent evidence has shown an increased risk of bronchiectasis in patients with rheumatoid arthritis who smoke. One study stated a tenfold increased prevalence of the disease in this cohort. Still, it is unclear as to whether or not cigarette smoke is a specific primary cause of bronchiectasis.
Other acquired causes of bronchiectasis involving environmental exposures include respiratory infections, obstructions, inhalation and aspiration of ammonia and other toxic gases, pulmonary aspiration, alcoholism, heroin (drug use), and various allergies.
Diagnosis for Bronchiectasis
The diagnosis of bronchiectasis is based on the review of clinical history and characteristic patterns in high-resolution CT scan findings. Such patterns include “tree-in-bud” abnormalities and cysts with definable borders. In one small study, CT findings of bronchiectasis and multiple small nodules were reported to have a sensitivity of 80%, specificity of 87%, and accuracy of 80% for the detection of bronchiectasis. Bronchiectasis may also be diagnosed without CT scan confirmation if clinical history clearly demonstrates frequent, respiratory infections, as well confirmation of an underlying problem via blood work and sputum culture samples.
Treatment of Bronchiectasis
Treatment of bronchiectasis is aimed at controlling infections and bronchial secretions, relieving airway obstruction, and preventing complications. This includes the prolonged usage of antibiotics to prevent detrimental infections, as well as eliminating accumulated fluid with postural drainage and chest physiotherapy. Surgery may also be used to treat localized bronchiectasis, removing obstructions that could cause progression of the disease.
Inhaled steroid therapy that is consistently adhered to can reduce sputum production and decrease airway constriction over a period of time, and help prevent progression of bronchiectasis. One commonly used therapy is beclometasone dipropionate, which is also used in asthma treatment. Use of inhalers such as albuterol (salbutamol), fluticasone (Flovent/Flixotide) and ipratropium (Atrovent) may help reduce likelihood of infection by clearing the airways and decreasing inflammation.
Mannitol dry inhalation powder, under the name Bronchitol, has been approved by the FDA for use in cystic fibrosis patients with or at risk for bronchiectasis. The original orphan drug indication approved in February 2005 allowed its use for the treatment of bronchiectasis. The original approval was based on the results of Phase II clinical studies showing the product to be safe, well-tolerated, and effective for stimulating mucus hydration/clearance, thereby improving quality of life in patients with chronic obstructive lung diseases like bronchiectasis. Long-term studies are underway as of 2007 to ensure the safety and effectiveness of the treatment.
Advair Diskus is also a commonly used inhaled corticosteroid which has in many cases been effective in clearing the airways, reducing sputum and reducing inflammation.
Prevention for Bronchiectasis
In order to prevent future development of bronchiectasis, an x-ray of the chest should be taken after any severe attack of measles, whooping cough or other acute respiratory infection in childhood. While smoking has not been found to be a direct cause of bronchiectasis, it is certainly an irritant that all patients should avoid in order to prevent the development of infections (such as bronchitis) and further complications.
A healthy body mass index, vaccination (especially against pneumonia and influenza) and regular doctor visits may have beneficial effects on the prevention of progressing bronchiectasis. The presence of hypoxemia, hypercapnia, dyspnea level and radiographic extent can greatly affect the mortality rate from this disease.
Homeopathy Treatment for Bronchiectasis
Keywords: homeopathy, homeopathic, treatment, cure, remedy, remedies, medicine
Homeopathy treats the person as a whole. It means that homeopathic treatment focuses on the patient as a person, as well as his pathological condition. The homeopathic medicines are selected after a full individualizing examination and case-analysis, which includes the medical history of the patient, physical and mental constitution, family history, presenting symptoms, underlying pathology, possible causative factors etc. A miasmatic tendency (predisposition/susceptibility) is also often taken into account for the treatment of chronic conditions. A homeopathy doctor tries to treat more than just the presenting symptoms. The focus is usually on what caused the disease condition? Why ‘this patient’ is sick ‘this way’. The disease diagnosis is important but in homeopathy, the cause of disease is not just probed to the level of bacteria and viruses. Other factors like mental, emotional and physical stress that could predispose a person to illness are also looked for. No a days, even modern medicine also considers a large number of diseases as psychosomatic. The correct homeopathy remedy tries to correct this disease predisposition. The focus is not on curing the disease but to cure the person who is sick, to restore the health. If a disease pathology is not very advanced, homeopathy remedies do give a hope for cure but even in incurable cases, the quality of life can be greatly improved with homeopathic medicines.
The homeopathic remedies (medicines) given below indicate the therapeutic affinity but this is not a complete and definite guide to the homeopathy treatment of this condition. The symptoms listed against each homeopathic remedy may not be directly related to this disease because in homeopathy general symptoms and constitutional indications are also taken into account for selecting a remedy. To study any of the following remedies in more detail, please visit the Materia Medica section at Hpathy.
None of these medicines should be taken without professional advice and guidance.
Homeopathy Remedies for Bronchiectasis:
Acet-ac., all-c., all-s., alumn., am-c., ant-t., ars., bac., bals-p., benz-ac., calc., cop., crot-h., eucal., ferr-i., gran., hep., ichth., kali-bi., kali-c., kreos., lyc., med., myos., myrt-c., phel., phos., puls., sang., sil., stann., sulph., tub.
- ^ Hassan, Isaac (2006-12-08). “Bronchiectasis“. eMedicine Specialties Encyclopedia. Gibraltar: WebMD. Retrieved on 2007-06-22.
- ^ Roguin, A (2006). “Rene Theophile Hyacinthe Laënnec (1781–1826): The Man Behind the Stethoscope”. Clin Med Res 4 (3): 230–35.
- ^ Wrong O (2003). “Osler and my father”. J R Soc Med 96 (6): 462–64. doi:10.1258/jrsm.96.9.462. PMID 12949207.
- ^ Morrissey BM (2007). “Pathogenesis of bronchiectasis”. Clin Chest Med 28 (2): 289–96. doi:10.1016/j.ccm.2007.02.014. PMID 17467548.
- ^ Mysliwiec, V, Pina, JS (1999). “Bronchiectasis: the ‘other’ obstructive lung disease”. Postgraduate Medicine 106 (1): 252–63.
- ^ Emmons, Ethan (2007-01-31). “Bronchiectasis“. eMedicine Specialties Encyclopedia. San Antonio, TX: WebMD. Retrieved on 2007-06-22.
- ^ Parker, Robert; Catherine Thomas, Lesley Bennett, et al (2007). Emergencies in Respiratory Medicine. Oxford, 206-207. ISBN 978-0-19-920244-7.
- ^ Morillas HN, Zariwala M, Knowles MR (2007). “Genetic Causes of Bronchiectasis: Primary Ciliary Dyskinesia”. Respiration 72 (3): 252–63. PMID 17534128.
- ^ Dalrymple-Hay MJ, Lucas J, Connett G, Lea RE (1999). “Lung resection for the treatment of severe localized bronchiectasis in cystic fibrosis patients”. Acta Chir Hung. 38 (1): 23–5. PMID 10439089.
- ^ Handelsman DJ, Conway AJ, Boylan LM, & Turtle JR (1984). “Young’s syndrome. Obstructive azoospermia and chronic sinopulmonary infections”. NEJM 310 (1): 3–9.
- ^ Shin MS, Ho KJ (1993). “Bronchiectasis in patients with alpha 1-antitrypsin deficiency. A rare occurrence?”. Chest 104: 1384–86. doi:10.1378/chest.104.5.1384.
- ^ Notarangelo LD, Plebani A, Mazzolari E, Soresina A, Bondioni MP (2007). “Genetic causes of bronchiectasis: primary immune deficiencies and the lung”. Respiration 74 (3): 264–75. doi:10.1159/000101784. PMID 17534129.
- ^ Catanzano, Tara (2005-09-05). “Primary Tuberculosis“. eMedicine Specialties Encyclopedia. Connecticut: WebMD. Retrieved on 2007-06-22.
- ^ Sheikh S, Madiraju K, Steiner P, Rao M (1997). “Bronchiectasis in pediatric AIDS”. Chest 112 (5): 1202–7. doi:10.1378/chest.112.5.1202. PMID 9367458.
- ^ Ferguson HR, Convery RP (2002). “An unusual complication of ulcerative colitis”. Postgrad. Med. J. 78: 503. doi:10.1136/pmj.78.922.503. PMID 12185236.
- ^ Kaushik, VV, Hutchinson D, Desmond J, Lynch MP, and Dawson JK (2004). “Association between bronchiectasis and smoking in patients with rheumatoid arthritis”. Annals of the Rheumatic Diseases 63: 1001–2. doi:10.1136/ard.2003.015123. PMID 15249329.
- ^ Lamari NM, Martins ALQ, Oliveira JV, Marino LC, Valério N (2006). “Bronchiectasis and clearence physiotherapy: emphasis in postural drainage and percussion” (in Portuguese). Braz. j. cardiovasc. surg. 21 (2).
- ^ Miller, JC (2006). “Pulmonary Mycobacterium Avium-Intracellular Infections in Women”. Radiology Rounds 4 (2).
- ^ Evans DJ, Bara AI,Greenstone M (2007). “Prolonged antibiotics for purulent bronchiectasis in children and adults”. Cochrane Database Syst Rev (2): CD001392. doi:10.1002/14651858.CD001392.pub2. PMID 17443506.
- ^ Otgün I, Karnak I, Tanyel FC, Senocak ME, Büyükpamukçu N (2004). “Surgical treatment of bronchiectasis in children“. J. Pediatr. Surg. 39 (10): 1532–6. PMID 15486899, http://linkinghub.elsevier.com/retrieve/pii/S0022346804004026.
- ^ Elborn JS, Johnston B, Allen F, Clarke J, McGarry J, Varghese G. (1992). “Inhaled steroids in patients with bronchiectasis”. Respir Med 86 (2): 121–4. doi:10.1016/S0954-6111(06)80227-1. PMID 1615177.
- ^ Reports, Consumer (2007-03-15). “Ipratropium and Albuterol Inhalation – Drug Review“. Consumer Reports of U.S.. Retrieved on 2007-06-22.
- ^ Waknine, Yael (2005-07-27). “Orphan Drug Approvals: Bronchitol, Prestara, GTI-2040“. Medscape today for WebMD. Retrieved on 2007-06-22.
- ^ Crofton J (1966). “Respiratory tract disease. Diagnosis and treatment of bronchiectasis. I. Diagnosis“. Br Med J 1 (5489): 721–3 contd. PMID 5909486.
- ^ Onen ZP, Eris Gulbay B, Sen E, Akkoca Yildiz O, Saryal S, Acican T, Karabiyikoglu G (2007). “Analysis of the factors related to mortality in patients with bronchiectasis”. Respir Med. 101 (7): 1390–97. doi:10.1016/j.rmed.2007.02.002. PMID 17374480.
Dr. Manish Bhatia
BHMS, BCA, M.Sc. Homeopathy (UCLAN, UK), CICH (IACH, Greece)
Dr. Manish Bhatia is the Founder Director of Hpathy.com, world’s leading homeopathy portal, serving homeopathy to more than half a million people every month. He is also Editor of Homeopathy for Everyone.
He runs a consultation office at Jaipur (Asha Homeopathy) and is one of the most well known Indian homeopaths globally. He has been practicing since 2001 and is helping Autism and other psychiatric patients since 2006. He was awarded Rajasthan’s foremost Raja Pajvan Dev Award For Excellence in the field of Medicine in 2015.
He has been working as an Asso. Professor of Organon of Medicine at S. K. Homeopathic Medical College since 2002. He was awarded with the prestigious APJ Abdul Kalam State Level Teacher’s Award in 2016. He has also given seminars and webinars in several countries of Europe, Americas and Australia.
He is the author of Lectures on Organon of Medicine Vol. I & II (English, Bulgarian, German editions), which are approved by the Central Council of Homeopathy (India) for BHMS and MD (Hom) syllabus. He is a contributing author to the book “Homeopathy and Mental Health Care: Integrative Practice, Principles and Research” and co-editor of “The Fireside Book of Homeopathy Tales.”